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1997
First report on systemic sclerosis with autologous haemopoietic stem cell transplantation
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1999
15-year follow-up report of allogenic bone marrow transplantation in systemic lupus erythematosus
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2000
First report of side effects related to GVHD
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2001
Strong myeloablation to reduce TRM
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2002
Objection to T cell depletion method
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2003
A complication was reported in rabbit ATG-administered patients.
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2005
First clinical study using autologous adipose-derived stem cells in Crohn's disease patients
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2007
Fludarabine + cyclophosphamide conditioning by replacing the existing BEAM: Described as conditioning focusing on immune regulation, not immune elimination
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2009
First RCT of expanded adipose-derived stem cells for the treatment of complex Perianal Fistula
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2010
Observe changes in immune cells with mucosal biopsy after MSC treatment
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2011
First report on efficacy and safety of Prochymal in Pediatric Patients
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2012
Immunomodulatory function and biological characteristics observed with MSC injection in Sjogren patient for the first time
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2012
Proof-of-concept study of MSC for the treatment of secondary progressive multiple sclerosis
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2013
Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn’s diseas
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2013
4-year follow-up report of allogeneic MSC
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2013
Fetal Membrane Cells for Treatment of Steroid-Refractory Acute Graft-Versus-Host Disease
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2014
Prochymal as a rescue agent for GVHD
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2014
Human placenta-derived cells (PDA-001) for the treatment of adults with multiple sclerosis
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2014
Third-Party Mesenchymal Stromal Cell Therapy for Refractory Acute Graft-versus-Host Disease
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2016
Allogeneic clonal mesenchymal stem cell therapy for refractory graft-versus-host disease to standard treatment
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2017
Cx611 for treatment of refractory rheumatoid arthritis
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2018
Adipose-derived mesenchymal stem cells (AdMSC) for the treatment of secondary progressive multiple sclerosis
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2018
First-in-man intravenous implantation of stromal vascular fraction in psoriasis
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2020
Phase 3 study of Prochymal for pediatrics patients
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2021
Phase 4 study of autologous adipose tissue-derived stem cell therapy for children with refractory Crohn’s complex fistula
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